肿瘤转移为恶性肿瘤致死和临床治疗远期疗效较差的主要因素 ,细胞粘附为转移过程的关键步骤之一。有关研究表明P 选择素 (P selectin)及其配体与肿瘤浸润、侵袭和转移灶形成有关 ,并有可能成为肿瘤转移的预后指标和肿瘤标志。但P selectin及其配体与肿瘤转移的关系 ,尤其是血小板P selectin与肿瘤癌栓形成和转移的关系仍有待进一步研究 Tumor metastasis is a major factor in the long-term curative effect of malignant tumor lethality and clinical treatment. Cell adhesion is one of the key steps in the metastatic process. Studies have shown that P selectin and its ligands are involved in tumor invasion, invasion and metastasis formation, and may be prognostic indicators and tumor markers of tumor metastasis. However, the relationship between P selectin and its ligands and tumor metastasis, especially the relationship between platelet P selectin and tumor thrombus formation and metastasis remains to be further studied.