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目的了解超敏-C反应蛋白(hs-CRP)与冠心病(CHD)不同类型病变的发生、发展因果关系,以便研究采取防治措施。方法选择CHD患者90例,其中包括急性心肌梗死(AM I)35例,不稳定性心绞痛(UAP)25例,稳定性心绞痛SAP 30例。采用免疫浊度法,测其患者血清内的hs-CRP含量,并进行对比分析和讨论。结果 CHD总体和各类型(AM I、UAP、SAP)的hs-CRP浓度与健康人对照组(NC)的结果比较,各类型CHD hs-CRP含量均高于对照组,差异有统计学意义(P<0.01);各类型CHD病变的hs-CRP异常百分率分别为UAP(88%)>AM I(85.7%)>SAP(53.7%)。UAP、AM I与SAP比较,差异均有统计学意义(P<0.01)。结论 hs-CRP与CHD多种危险因素有关,hs-CRP水平是反映冠状动脉粥样病变的炎症、炎性反应的主要指标,对预测CHD各类型病变动态及心血管事件有重要价值。
Objective To understand the occurrence of different types of lesions of hs-CRP and CHD and to develop the causal relationship so that we can take preventive measures. Methods Ninety patients with CHD were selected, including 35 cases of acute myocardial infarction (AMI), 25 cases of unstable angina pectoris (UAP) and 30 cases of stable angina pectoris (SAP). Using the method of immunoturbidimetry, the content of hs-CRP in the serum of patients was measured and compared and analyzed. Results The levels of hs-CRP in all CHD groups and all types (AM I, UAP, SAP) were significantly higher than those in healthy controls (NC) P <0.01). The percentages of abnormal hs-CRP in all types of CHD were UAP (88%)> AMI (85.7%)> SAP (53.7%). UAP, AM I compared with SAP, the difference was statistically significant (P <0.01). Conclusions hs-CRP is associated with multiple risk factors of CHD. The level of hs-CRP reflects the inflammatory and inflammatory responses of coronary atherosclerotic lesions. It has important value in predicting various types of CHD lesions and cardiovascular events.