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为了解大鼠胆管梗阻后内皮素在肝、肾、胃、肺组织及血液中的分泌状况以探讨内皮素在梗阻性黄疸中的作用。用放射免疫法（Radioimmunoassay．RIA）测量大鼠胆管梗阻后5、10、15、20、25d时肝、肾、胃、肺组织及血液中内皮素的含量以及肝组织、血液中甘胆酸的含量，组织切片观察上述组织的病理改变。血液及肝组织中内皮素和甘胆酸含量呈进行性升高，且二者升高水平呈正相关（P＜0．05）。肾、胃、肺组织中内皮素含量亦相继升高（P＜0．05）。病理组织切片显示随胆管梗阻时间延长上述组织均呈进行性损害，提示内皮素可能是参与梗阻性黄疸肝脏损伤的重要因素之一，并且对梗阻性黄疸后多系统器官衰竭的触发可能具有重要的病理生理意义。
In order to understand the secretion of endothelin in the liver, kidney, stomach, lung tissue and blood after biliary obstruction in rats to explore the role of endothelin in obstructive jaundice. Radioimmunoassay (Radioimmunoassay.RIA) at 5,10,15,20,25d after rat bile duct obstruction liver, kidney, stomach, lung tissue and blood levels of endothelin and liver tissue, the blood of glycocholate Content, histological sections to observe the pathological changes of the above tissues. The content of endothelin and glycocholic acid in blood and liver tissues increased progressively, and the levels of both were positively correlated (P <0.05). Endothelin levels in kidney, stomach and lung tissues also increased (P <0.05). Pathological sections showed that the above tissues were progressive damage with prolonged biliary obstruction, suggesting that endothelin may be one of the important factors involved in liver injury in obstructive jaundice and may be important in triggering multi-system organ failure after obstructive jaundice Pathophysiological significance.