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目的:探讨外周血癌胚胎抗原(CEA)、糖类抗原CA153、CA125在乳腺癌临床筛查及诊断中的应用价值。方法:选取2014年1~12月在该院做乳腺检查的154例妇女为研究对象,其中54例乳腺癌患者为乳腺癌组、50例乳腺良性肿瘤为乳腺良性肿瘤组、50例健康体检者为健康妇女组。应用ELISA法测定,测定3组外周血CEA、CA153、CA125水平,采用受试者特异曲线(ROC)分析3种肿瘤标志物对乳腺癌筛查及诊断价值。结果:乳腺癌患者外周血CEA、CA153、CA125水平显著高于其他两组,差异有统计学意义(P<0.05),乳腺良性肿瘤组与健康组外周血CEA、CA153、CA125水平差异无统计学意义(P>0.05)。与TNMⅠ~Ⅱ期患者相比,TNMⅢ~Ⅳ期外周血CEA、CA153、CA125水平较高,差异有统计学意义(P<0.05)。经ROC曲线分析可知,CEA、CA153、CA125联合检测时灵敏度、特异度高于单一指标(P<0.05)。结论:外周血CEA、CA153、CA125水平对鉴别乳腺癌具有临床价值,联合检测可提高诊断效能。
Objective: To investigate the clinical value of CEA, CA153 and CA125 in clinical screening and diagnosis of breast cancer. Methods: A total of 154 women who underwent breast examination from January to December 2014 in our hospital were enrolled. Among them, 54 were breast cancer patients, 50 were benign breast tumors and 50 were healthy For healthy women group. Serum levels of CEA, CA153 and CA125 in 3 groups of peripheral blood were measured by ELISA, and the screening and diagnostic value of 3 tumor markers for breast cancer were analyzed by receiver operating characteristic curve (ROC). Results: The levels of CEA, CA153 and CA125 in peripheral blood of patients with breast cancer were significantly higher than those in the other two groups (P <0.05). There was no significant difference in the levels of CEA, CA153 and CA125 between benign and malignant breast tumors Significance (P> 0.05). The levels of CEA, CA153 and CA125 in peripheral blood of patients with TNM Ⅲ ~ Ⅳ were higher than those of patients with TNM Ⅰ ~ Ⅱ, the difference was statistically significant (P <0.05). The ROC curve analysis showed that the sensitivity and specificity of CEA, CA153 and CA125 were higher than single indexes (P <0.05). Conclusion: The levels of CEA, CA153 and CA125 in peripheral blood have clinical value in the differential diagnosis of breast cancer. Combined detection can improve the diagnostic efficiency.