内眼手术后,或多或少可发生强烈的纤维蛋白反应,这种反应妨碍适当的术后检查,并可导致瞳孔阻滞性青光眼。已知用肝素能抑制纤维蛋白形成,但可增加眼内出血的频率。annexin V 是新近分离的 annexin 族7个成员之一,已证明有抗炎和抗血栓形成功能。作者研究了标准化家兔手术模型房内 annexin V防止纤维蛋白形成的效力,并与房内肝素相比较。研究用体重2.0至2.5kg 的新西兰白色家兔。手术操作过程按 Johnson 等的方法稍加修改:在角膜缘后1mm 处作巩膜切开术,然 After intraocular surgery, a more or less intense fibrin reaction can occur, a reaction that hinders proper postoperative examination and can lead to pupillary block glaucoma. It is known that heparin inhibits fibrin formation but increases the frequency of intraocular hemorrhage. Annexin V, one of the seven newly isolated members of the annexin family, has demonstrated anti-inflammatory and anti-thrombotic effects. The authors studied the efficacy of annexin V in preventing fibrin formation in a standardized rabbit surgery model and compared it with in-house heparin. New Zealand white rabbits weighing 2.0 to 2.5 kg were studied. Surgical procedure was modified slightly by the method of Johnson et al .: Scleotomy at 1 mm posterior to limbal margin, however