目的了解医院住院病区抗生素的临床应用及细菌耐药状况,指导临床合理用药。方法对2014年住院病区抗生素的临床应用及细菌耐药情况进行回顾性调查。结果由于广谱抗生素的频繁使用,加速了细菌耐药的进程,细菌耐药呈逐年递增的趋势。结论为避免细菌耐药的快速发展,应加强抗生素临床应用的监督和管理,合理使用抗生素是关键。 Objective To understand the clinical application of antibiotics in hospital inpatient wards and the status of bacterial resistance and to guide clinical rational use of drugs. Methods The clinical application and antibiotic resistance of antibiotics in inpatients in 2014 were retrospectively investigated. The results of frequent use of broad-spectrum antibiotics to speed up the process of bacterial resistance, bacterial resistance showed a trend of increasing year by year. Conclusion To avoid the rapid development of bacterial resistance, we should strengthen the supervision and management of clinical application of antibiotics. The rational use of antibiotics is the key.