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对30例急性白血病(AL)自体骨髓移植(ABMT)后造血功能恢复进行了单因素和多因素分析。移植后WBC>1.0×10 ̄9/L、ANC>0.5×10 ̄9/L、BPC>20×10 ̄9/L和胸骨髓增生活跃的中位时间分别为30,37,61和50天。白血病类型(急性髓细胞白血病)和骨髓细胞-196℃冻存是造血功能尤其是血小板延期恢复的主要因素(P<0.05),而年龄、性别、缓解(CR)至ABMT间期、停化疗至采髓及移植的间期、预处理方案及回输的骨髓细胞量等对造血功能的恢复无明显影响(P>0.1)。血小板的延期恢复造成输血及血小板量明显增加和住院时间明显延长(P<0.01)。移植后90天BPC<20×10 ̄9/L者早期复发的可能性较大(P=0.06)。
The univariate and multivariate analysis of hematopoietic function recovery after autologous bone marrow transplantation (ABMT) in 30 patients with acute leukemia was performed. After transplantation, the median time for WBC>1.0×10 ̄9/L, ANC>0.5×10 ̄9/L, BPC>20×10 ̄9/L, and thoracic bone marrow hyperplasia was 30,37, respectively. 61 and 50 days. The type of leukemia (acute myeloid leukemia) and cryopreservation of bone marrow cells at -196°C are the main factors for hematopoietic function, especially delayed platelet recovery (P<0.05), and age, sex, remission (CR) to ABMT interval, and duration The period from chemotherapy to harvesting marrow and transplantation, the pretreatment regimen, and the amount of bone marrow cells reinfused had no significant effect on the recovery of hematopoietic function (P>0.1). Delayed platelet recovery resulted in significant increases in blood transfusion and platelet counts and significantly longer hospital stay (P<0.01). 90 days after transplantation, BPC<20×10 ̄9/L was more likely to have early recurrence (P=0.06).