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目的:总结18例卵巢癌术后复发患者经介入动脉插管化疗的疗效,并对栓塞剂的应用进行了初步探讨。材料和方法:采用经皮股动脉穿刺双侧髂内动脉选择性插管的方法进行化疗灌注和栓塞。化疗方案为卡铂+表阿霉素(简称:CA方案),3例在CA方案的基础上加用足叶乙甙(VP-16),5例同时进行髂内动脉栓塞,所用栓塞材料包括明胶海绵碎块(2例)、顺铂微球(2例)、碘化油(1例)。结果:在15例可评价疗效的病例中,CR1例,PR6例,MR5例,SD2例,PD1例,有效率CR+PR为46.6%(7/15)。结论:动脉插管化疗是卵巢癌术后复发较合理的辅助疗法;卡铂+表阿霉素化疗方案对卵巢癌术后复发有较好疗效;进行髂内动脉栓塞化疗时选用明胶海绵碎块作栓塞剂,副作用较少。
OBJECTIVE: To summarize the curative effect of interventional arterial catheterization in 18 patients with postoperative recurrence of ovarian cancer, and to explore the application of embolic agent. MATERIALS AND METHODS: Percutaneous transhepatic arterial puncture of bilateral internal iliac arteries was used to perform chemoembolization and embolization. The chemotherapy regimen consisted of carboplatin + epirubicin (abbreviated: CA regimen), 3 cases of etoposide (VP-16) on the basis of CA regimen, and 5 cases of internal iliac artery embolization. The embolic materials used included Gelatin sponge fragments (2 cases), cisplatin microspheres (2 cases), iodized oil (1 case). Results: Of the 15 evaluable cases, CR1, PR6, MR5, SD2 and PD1 had an effective CR + PR of 46.6% (7/15). Conclusion: Arterial intubation chemotherapy is a more appropriate adjuvant therapy for postoperative recurrence of ovarian cancer; Carboplatin + epirubicin chemotherapy regimen has a good effect on postoperative recurrence of ovarian cancer; gelatin sponge fragment As embolic agent, fewer side effects.