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The current study examined a rat model of vascular dementia.The model rats exhibited obvious morphological and ultrastructural changes in neurons in the brain,and significantly reduced dynamin 1 expression in hippocampal CA1 region along with decreased learning and memory performance.Following atorvastatin treatment,the morphology and ultrastructure of cells in the model rat brain were significantly improved,dynamin 1 expression in hippocampal CA1 region was significantly enhanced,and learning and memory ability was significantly improved.The results demonstrated that impaired learning and memory abilities in vascular dementia model rats were closely correlated with decreased dynamin 1 expression.These findings indicate that atorvastatin can protect model rats against cognitive impairment by increasing dynamin 1 expression.
The current study examined a rat model of vascular dementia. The model rats exhibit obvious morphological and ultrastructural changes in neurons in the brain, and significantly reduced dynamin 1 expression in hippocampal CA1 region along with decreased learning and memory performance. Popular atorvastatin treatment, the morphology and ultrastructure of cells in the model rat brain were significantly improved, dynamin 1 expression in hippocampal CA1 region was significantly enhanced, and learning and memory ability was significantly improved. The results demonstrated that impaired learning and memory abilities in vascular dementia model with decreased dynamin 1 expression. These findings indicate that atorvastatin can protect model rats against cognitive impairment by increasing dynamin 1 expression.