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目的探讨三维适形放疗非小细胞肺癌近期疗效及其影响因素。方法三维适形放疗110例未手术非小细胞肺癌患者,于放疗前行99mTc-MIBI肺显像。应用χ2和Logistic多元回归分析方法研究肺癌患者临床病理资料、物理参数及99mTc-MIBI肺显像指标与三维适形放疗近期疗效的关系。结果放疗后完全缓解29.0%(32/110),部分缓解58.2%(64/110),全组患者有效率87.3%(96/110)。单因素分析有统计学意义的相关因素是卡氏评分、血红蛋白水平、肿瘤大小、淋巴结转移情况、放疗时间、放疗增敏情况及ER和DR(P<0.05);经Logistic回归模型分析,血红蛋白、肿瘤大小、放疗时间、放疗增敏及DR为影响3D-CRT近期疗效的独立因素(P<0.05)。结论3D-CRT能有效缓解患者的症状,血红蛋白、肿瘤大小、放疗时间、放疗增敏及DR为影响3D-CRT近期疗效的独立因素。
Objective To investigate the short-term curative effect and influencing factors of three-dimensional conformal radiation therapy for non-small cell lung cancer. Methods Three-dimensional conformal radiotherapy in 110 cases of non-surgical non-small cell lung cancer patients before radiotherapy 99mTc-MIBI lung imaging. Chi-square and Logistic multiple regression analysis were used to study the relationship between clinical and pathological data, physical parameters and 99mTc-MIBI lung imaging and the short-term efficacy of three-dimensional conformal radiotherapy. Results The complete remission was 29.0% (32/110) after radiotherapy, 58.2% (64/110) partial remission and 87.3% (96/110) in the whole group. Univariate analysis showed that the related factors of Karnofsky index, hemoglobin level, tumor size, lymph node metastasis, radiotherapy time, radiosensitivity and ER and DR (P <0.05); Logistic regression model analysis, hemoglobin, Tumor size, radiotherapy time, radiosensitivity and DR were the independent factors affecting the short-term efficacy of 3D-CRT (P <0.05). Conclusion 3D-CRT can effectively alleviate the symptoms, hemoglobin, tumor size, radiotherapy time, radiosensitivity and DR are the independent factors affecting the short-term efficacy of 3D-CRT.