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目的:比较青年和老年非小细胞肺癌手术患者临床特点和术后生存率。方法:我院1997-2002年胸外科肺癌手术患者,根据初诊时的年龄随机选择非小细胞肺癌患者40例作为青年组(≤40岁)和50例作为老年组(≥70岁)。对比两组患者的年龄、性别、吸烟史、伴随疾病、病理类型、临床分期、手术方式、术后并发症、5年生存率。结果:青年组的伴随疾病发生率(22.5%)明显低于老年组(50.0%)(P=0.034);青年组的腺癌发生率(52.5%)明显高于老年组(12.0%)(P=0.008),而青年组的鳞癌发生率(32.5%)明显低于老年组(78.0%)(P=0.016);青年组术后并发症发发生率(12.5%)明显低于老年组(32.0%)(P=0.026);青年组5年总生存率(32.2%)明显高于老年组(20.5%)(P=0.041)。结论:青年非小细胞肺癌患者以腺癌多见,5年总生存率高于老年组,这可能与老年人伴随疾病和术后并发症较多有关。
OBJECTIVE: To compare the clinical features and postoperative survival of young and elderly non-small cell lung cancer patients. Methods: Forty patients with non-small cell lung cancer (NSCLC) were randomly selected as the youth group (≤40 years) and 50 as the elderly group (≥70 years) from January 1997 to December 2002. The age, gender, smoking history, concomitant diseases, pathological types, clinical stage, surgical methods, postoperative complications and 5-year survival rate were compared between the two groups. Results: The incidence of concomitant diseases (22.5%) in young group was significantly lower than that in elderly group (50.0%) (P = 0.034). The incidence of adenocarcinoma in young group was significantly higher than that of elderly group (52.5% vs 12.0% = 0.008). The incidence of squamous cell carcinoma in young group (32.5%) was significantly lower than that in elder group (78.0%) (P = 0.016). The incidence of postoperative complications in young group (12.5% 32.0%) (P = 0.026). The 5-year overall survival rate (32.2%) in youth group was significantly higher than that in elderly group (20.5%) (P = 0.041). CONCLUSIONS: Most of patients with non-small cell lung cancer are adenocarcinomas. The 5-year overall survival rate is higher than that in the elderly group, which may be related to the elderly patients with more diseases and postoperative complications.