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亚急性海绵状脑病(简称CJD)是非常规慢病毒惑染的进行性中枢神经系统广泛受累的疾病。临床特点是进行性意识障碍、痴呆、肌阵挛发怍、肌强直、锥体束、锥体外束和小脑损害等体征。病理特点是不同程度的海绵状改变、神经细胞脱失和星形细胞增生等。Gibbs等首次用CJD病人脑组织接种黑猩猩脑内发病,以后相继在灵长类和非灵长类动物接种发病,病理改变与人类CJD相似,但人类自然传染方式仍不清。本病发病率在北美及其它西方国家约1/1000000/年,我国近年来亦有个案报道,
Subacute spongiform encephalopathy (CJD) is an unconventional lentivirus infection of the progressive central nervous system involvement disease. Clinical features include progressive disturbance of consciousness, dementia, myoclonus 怍, myotonia, pyramidal tract, extrapyramidal and cerebellar lesions and other signs. Pathological features are varying degrees of sponge-like changes, nerve cell loss and astrocytosis. Gibbs and other first inoculated with brain tissue of CJD patients with chimpanzee brain disease, later in the primates and non-primate inoculation onset, pathological changes similar to human CJD, but the natural way of human infection is still unclear. The incidence of this disease in North America and other Western countries about 1/1000000 / year, China has reported cases in recent years,