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A highly sensitive and simple Rayleigh light scattering (RLS) method for the determination of ciprofloxacin hydrochlo-ride has been developed. Ciprofloxacin hydrochloride (CPFH) reacted with tetraphenylboron sodium(TPB) to form an ion-association complex in pH 5.31 aqueous solution, which re-sulted in a significant enhancement of the RLS intensity, which was linear with the concentration of CPFH in the range of 12.7-419 ng·mL-1. The limit of detection for CPFH was 6.99 ng·mL-1. The method is simple, highly sensitive and selective within a wide linear range. Applying this method for the determi-nation of ciprofloxacin hydrochloride in pharmaceutical prepara-tions and biological fluids obtained satisfactory results.
A highly sensitive and simple Rayleigh light scattering (RLS) method for the determination of ciprofloxacin hydrochlo-ride has been developed. Ciprofloxacin hydrochloride (CPFH) reacted with tetraphenylboron sodium (TPB) to form an ion-association complex in pH 5.31 aqueous solution, which re-sulted in a significant enhancement of the RLS intensity, which was linear with the concentration of CPFH in the range of 12.7-419 ng · mL-1. The limit of detection for CPFH was 6.99 ng · mL-1. The method is simple, highly sensitive and selective within a wide linear range. Applying this method for the determination-nation of ciprofloxacin hydrochloride in pharmaceutical prepara- tions and biological fluids succeeded results.