组织供氧的减少 (缺氧 )是由多种原因引起的 ,也是各种疾病产生的因素之一。细胞和组织对缺氧的反应是不同的 ,包括在代谢需求、细胞基因产物的调节及脂类和蛋白质类介质的释放上都有显著的变化。但与缺氧有关的疾病的治疗靶标方面研究很少 ,本文阐述与缺氧反应有关的细胞和分子生物学方面的最新进展 ,探讨用来研究缺氧及介入疗法的潜在靶标。 Reduction of tissue oxygen supply (hypoxia) is caused by a variety of causes and is also one of the contributing factors to various diseases. Cells and tissues respond differently to hypoxia, including significant changes in metabolic requirements, regulation of cellular gene products, and release of lipid and protein-based mediators. However, there are few studies on the therapeutic targets of hypoxia-related diseases. This article describes the recent advances in cellular and molecular biology related to hypoxia and explores potential targets for hypoxia and interventional therapy.