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甲状腺激素抗性综合征的特点是甲状腺肿大,血中游离甲状腺激素增高,但无甲状腺中毒症状。本文报导一甲状腺激素抗性家族。该家族19名(四代人)成员中有8名本症患者。研究结果表明其发病情况符合常染色体显性遗传的方式。受累的家族成员均有甲状腺肿,临床上甲状腺功能正常,血清甲状腺激素的水平显著增高:甲状腺素(T_4)=21.1±2.1μg/dl;三碘甲腺原氨酸(T_3)=323±60ng/dl;游离T_4=5.4±0.9ng/dl;游离T_3=1,134±
Thyroid hormone syndrome is characterized by goiter, free blood thyroid hormone increased, but no symptoms of thyroid poisoning. This article reports a family of thyroid hormone resistance. Nine of the 19 (four generations) members of the family have eight patients with the disease. The results show that its incidence consistent with autosomal dominant manner. The affected family members had goiter, the clinical thyroid function is normal, serum thyroid hormone levels were significantly increased: thyroid hormone (T_4) = 21.1 ± 2.1μg / dl; triiodothyronine (T_3) = 323 ± 60ng / dl; free T_4 = 5.4 ± 0.9 ng / dl; free T_3 = 1,134 ±