目的了解贵阳市新生儿苯丙酮尿症的发病率 ,探讨用细菌抑制法作新生儿苯丙酮尿症筛查在我市乃至我省推广应用的可能性及方法学等问题。方法用Guthrie细菌抑制法。结果筛查出一例苯丙酮尿症患儿。结论用Guthrie细菌抑制法作新生儿苯丙酮尿症筛查推广使用是可行的。 Objective To understand the incidence of neonatal phenylketonuria in Guiyang and to explore the possibility and methodology of using bacterial inhibition as a screening tool for neonatal phenylketonuria in our city and even in our province. Methods Guthrie bacterial inhibition method. Results A sample of children with phenylketonuria was screened. Conclusion Guthrie bacterial inhibition of neonatal phenylketonuria screening is feasible.