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目的探究亚低温治疗新生儿缺氧缺血性脑病后S100-β蛋白、NSE变化的意义。方法随机选取该院收治的90例缺氧缺血性脑病新生儿,分为对照组和试验组,每组45例患儿,对照组给予常规治疗,试验组给予亚低温治疗,对比分析两组患儿的治疗效果。结果试验组患儿治疗后总有效率(95.55%)明显高于对照组患儿(55.56%),差异有统计学意义(χ~2=19.492 0,P<0.05)。试验组患儿治疗后72 h S100-β蛋白(1.78±0.20)ng/ml及NSE(16.45±1.68)ng/ml、7 d S100-β蛋白(1.02±0.09)ng/ml及NSE(7.47±0.06)ng/ml明显优于对照组患儿72 h S100-β蛋白(2.89±0.27)ng/ml及NSE(28.19±4.11)ng/ml、7d S100-β蛋白(2.14±0.13)ng/ml及NSE(17.49±1.28)ng/ml。试验组患儿治疗后神经功能评分(37.82±1.88)明显高于对照组患儿(33.15±1.93)。结论亚低温治疗新生儿缺氧缺血性脑病效果显著,能够促进S100-β蛋白、NSE水平恢复,改善神经功能。
Objective To investigate the changes of S100-β protein and NSE after hypothermia treatment of neonatal hypoxic-ischemic encephalopathy. Methods A total of 90 newborns with hypoxic-ischemic encephalopathy were randomly divided into control group and experimental group, with 45 cases in each group. The control group was given routine treatment, and the experimental group was given hypothermia treatment. The two groups were compared Children’s treatment. Results The total effective rate (95.55%) in the experimental group was significantly higher than that in the control group (55.56%), the difference was statistically significant (χ ~ 2 = 19.492 0, P <0.05). The levels of S100-βprotein (1.78 ± 0.20) ng / ml and NSE (16.45 ± 1.68) ng / ml, S100-βprotein on day 7 (1.02 ± 0.09) ng / ml and NSE (2.89 ± 0.27) ng / ml and NSE (28.19 ± 4.11) ng / ml, 7d S100-βprotein (2.14 ± 0.13) ng / ml And NSE (17.49 ± 1.28) ng / ml. The score of neurological function (37.82 ± 1.88) in the experimental group was significantly higher than that in the control group (33.15 ± 1.93). Conclusion Mild hypothermia treatment of neonatal hypoxic-ischemic encephalopathy significant effect, can promote S100-β protein, NSE levels restored and improve neurological function.