聚乙二醇1000(PEG1000)是较有代表性的牛顿流体类药用辅料,各国药典收载的PEG1000的黏度测定方法各不相同。本研究通过试验确定了测定其运动黏度的方法 :制备50%的PEG 1000水溶液,用流出时间不少于200 s的平氏毛细管黏度计,在(20±0.1)℃条件下测定。并采用流变仪验证该方法。结果表明,该方法简便、准确、重现性好。 Polyethylene glycol 1000 (PEG1000) is a representative Newtonian fluid pharmaceutical excipients, the pharmacopoeial countries contained PEG1000 viscosity measurement methods vary. In this study, we determined the kinematic viscosity of the solution by testing: 50% aqueous solution of PEG 1000 was prepared and measured with a capillary viscometer with a flow-out time of not less than 200 s at (20 ± 0.1) ° C. The rheometer was used to verify the method. The results show that the method is simple, accurate and reproducible.