Fulton B等对多沙唑嗪的临床药理学及其应用进行了综述。多沙唑嗪是一种长效的α1肾上腺素受体阻滞剂,结构与派唑嗪和特拉唑嗪有关。对于良性前列腺增生(BPH),多沙唑嗪通过阻滞α1肾上腺素受体降低前列腺平滑肌张力,减轻梗阻膀胱流出率。多沙唑嗪已被应用于各种人群(包括老年人、黑人、吸烟者)和各种合并症患者(如肾功不全、高血脂、非胰岛素依赖糖尿病(NIDDM)及呼吸道疾病)。多沙唑嗪也被成功地合用利尿剂、钙管道阻滞剂、血管紧张素 Fulton B and so on doxazosin clinical pharmacology and its application are reviewed. Doxazosin is a long-acting alpha 1 adrenergic blocker with a structure that is related to the presence of prazosin and terazosin. For benign prostatic hyperplasia (BPH), doxazosin reduces the bladder outflow obstruction by blocking the α1-adrenergic receptor to reduce prostate smooth muscle tension. Doxazosin has been used in various populations (including the elderly, blacks, smokers) and various comorbidities (such as renal insufficiency, hyperlipidemia, non-insulin-dependent diabetes mellitus (NIDDM) and respiratory diseases). Doxazosin has also been successfully combined diuretics, calcium pipe blockers, angiotensin