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概述近年来大量资料表明骨髓细胞染色体分析在白血病研究中有着重要价值。某些特异性染色体改变与白血病细胞形态及临床特征有着较密切的关系。因此,将染色体改变与形态学分型相结合可作出更细致的亚型分类,以便更确切地判断病情,指导治疗。目前,在白血病中许多染色体畸变的预后意义已被肯定,故有作者提出染色体改变可作为急性白血病估计预后的独立指标。某些特异性很强的染色体异常,如急性非淋巴细胞白血病M_3型的15/17易位,具诊断价值。急性白血病经治疗获得缓解时染色体异常往往消失,复发时再现,故在缓解期定时复查骨髓细胞染色体可用以预测复发。近年来随着分子遗传学技术的发展认为染色体断裂在恶变始发过程中起重要作用,因此白血病染色体研究对本病发病机理的探索也具有十分重要的意义。急性非淋巴细胞白血病(急非淋)的染色体异常
Summary In recent years, a large number of data show that bone marrow cell chromosome analysis has important value in the study of leukemia. Some specific chromosome changes and leukemia cell morphology and clinical features are closely related. Therefore, the combination of chromosomal changes and morphological typing can be more subtle sub-classification, in order to more accurately determine the condition, to guide the treatment. Currently, the prognostic significance of many chromosomal aberrations in leukemia has been affirmed, so the authors suggest that chromosomal alterations may serve as independent prognostic indicators for acute leukemia. Some very specific chromosomal abnormalities, such as 15/17 translocations of M_3 type of acute non-lymphocytic leukemia, have diagnostic value. Acute leukemia remission after treatment often disappear chromosomal abnormalities, recurrence recurrence, so the timing of remission in the remission of bone marrow cell chromosomes can be used to predict recurrence. In recent years, with the development of molecular genetics technology that chromosomal rupture plays an important role in the process of malignant transformation, so the research of leukemia chromosome on the pathogenesis of this disease is also of great significance. Chromosomal abnormalities in acute non-lymphocytic leukemia (acute non-lymphocytic leukemia)