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目的分析男性乳腺癌(MBC)的临床病理特点及免疫表型,提高对MBC的认识。方法回顾性分析15例MBC患者的临床表现、肿瘤大小、淋巴结转移、病理形态学及免疫表型等特点。结果MBC占同期男性乳腺疾病的25%,占同期乳腺癌的1.19%。患者平均年龄为57.5(30～78)岁。从出现症状至就诊时间为1个月至10年,平均13.9个月。53.33%(8/15)的MBC位于左侧乳腺,26.67%(4/15)位于右侧,双侧者6.67%(1/15)。肿块<2 cm者4例,2～5 cm者7例,5～10 cm者4例。86.67%(13/15)为非特殊型浸润性导管癌,6.67%(1/15)为乳头状癌,6.67%(1/15)为浸润性小叶癌。MBC的形态学特点为伴有乳头的巢团状结构,粉刺样坏死少见。33.33%(5/15)的MBC伴腋窝淋巴结转移。9例行免疫组化检测显示:ER阳性6例(66.67%);PR阳性7例(77.78%);CerbB-2阳性4例(44.44%);p53阳性4例(44.44%);Ki-67细胞增殖指数<25%者4例(44.44%),25%～50%者3例(33.33%),>50%者1例(11.11%)。结论MBC发病比例低,年龄偏大,就诊已属晚期,临床表现为无痛性的乳腺区域肿块。组织学上以非特异型浸润性导管癌为主,具有乳头的巢团状结构,淋巴结转移较少。
Objective To analyze the clinicopathological characteristics and immunophenotype of male breast cancer (MBC) and to improve the understanding of MBC. Methods The clinical manifestations, tumor size, lymph node metastasis, pathomorphology and immunophenotype of 15 patients with MBC were retrospectively analyzed. Results MBC accounted for 25% of male breast diseases in the same period, accounting for 1.19% of breast cancer in the same period. The average age of patients was 57.5 (30-78) years. From the onset of symptoms to treatment time of 1 month to 10 years, an average of 13.9 months. 53.33% (8/15) MBC were located in the left breast, 26.67% (4/15) in the right side and 6.67% (1/15) in both sides. 4 cases with mass <2 cm, 7 cases with 2 ~ 5 cm, and 4 cases with 5 ~ 10 cm. 86.67% (13/15) were nonspecific invasive ductal carcinoma, 6.67% (1/15) were papillary carcinoma and 6.67% (1/15) were invasive lobular carcinoma. The morphological features of MBC are nest-like structures with papillae, with rare acne-like necrosis. 33.33% (5/15) MBC with axillary lymph node metastasis. Nine routine immunohistochemical examinations showed that 6 cases (66.67%) were positive for ER, 7 cases (77.78%) were positive for PR, 4 cases were positive for CerbB-2 (44.44%), 4 cases were positive for p53 There were 4 cases (44.44%) with cell proliferation index <25%, 3 cases (33.33%) with 25% ~ 50%, and 1 case (11.11%) with> 50% Conclusions The incidence of MBC is low, the age is relatively high, and the clinic is advanced. The clinical manifestations are painless breast mass. Histologically non-specific infiltrative ductal cancer-based, with a nipple dangling structure, lymph node metastasis less.