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重症型肝炎是病毒性肝炎中最严重的临床类型,预后差,病死率高达60～90％。由于各地诊断标准不一,报告的疗效也不同。 重症型肝炎致死的原因为肝性昏迷、脑水肿、大出血及肝肾综合征等。出血倾向是重症型肝炎的一个主要临床特征;1970年Rake报告暴发型肝炎(急性重症型)病人的出血倾向,除肝脏合成各种凝血因子减少外,可能与弥散性血管内凝血有关。此后,国内外相继有一些应用肝素治疗重症型肝炎的报告。本文报告1974年9月至1976年9月我院应用肝素、中药等综合疗法治疗重症肝炎17例,并报告一例急性重症型肝炎(暴发型肝炎)尸检,病理检查证实有弥散性血管内凝血存在。
Severe hepatitis is the most serious clinical type of viral hepatitis, the prognosis is poor, the mortality rate as high as 60 to 90%. Because of different diagnostic criteria around the reported efficacy is also different. Severe hepatitis cause of death for hepatic coma, cerebral edema, bleeding and hepatorenal syndrome. Bleeding tendency is a major clinical feature of severe hepatitis; in 1970, Rake reported bleeding tendency in patients with fulminant hepatitis (acute severe type), which may be associated with disseminated intravascular coagulation, in addition to reduced synthesis of various clotting factors in the liver. Since then, there have been some reports of heparin treatment of severe hepatitis at home and abroad. This article reports from September 1974 to September 1976 in our hospital heparin, traditional Chinese medicine and other comprehensive treatment of 17 cases of severe hepatitis, and reported a case of acute severe hepatitis (fulminant hepatitis) autopsy, pathological examination confirmed the presence of disseminated intravascular coagulation .