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[目的]观察临床急性心肌梗死(AMI)患者血清瘦素水平的变化,探讨其临床意义。[方法]随机选取临床研究对象68例,其中AMI组患者36例,正常对照组32例。所有研究对象均测定血压(Bp)、血清甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高敏C-反应蛋白(hs-CRP)和瘦素水平。[结果]与正常对照组比较,AMI组患者的Bp、TC、LDL-C、hs-CRP和瘦素水平均有明显升高(P﹤0.05),而两组间TG无明显差别。AMI患者的瘦素水平与hs-CRP有明显的正相关性(r=0.319,P﹤0.05)。[结论]AMI患者瘦素水平明显升高,提示它可能是一种重要的损伤因子,在AMI的发病中起重要作用。
[Objective] To observe the change of serum leptin level in patients with clinical acute myocardial infarction (AMI) and discuss its clinical significance. [Method] Sixty-eight clinical subjects were selected randomly, including 36 patients in AMI group and 32 in normal control group. All subjects were measured blood pressure (Bp), serum triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high sensitivity C-reactive protein (hs-CRP) and leptin levels. [Results] Compared with the normal control group, the levels of Bp, TC, LDL-C, hs-CRP and leptin in AMI group were significantly increased (P <0.05), but there was no significant difference between the two groups. There was a significant positive correlation between leptin level and hs-CRP in patients with AMI (r = 0.319, P <0.05). [Conclusion] The leptin level in patients with AMI is significantly increased, suggesting that it may be an important injury factor and play an important role in the pathogenesis of AMI.