肿瘤组织乏氧是恶性实体肿瘤的一个重要生物学特征,其乏氧程度与临床放疗效果密切相关,许多研究表明肿瘤组织的乏氧程度与其对放疗的抵抗性呈正相关。因此,识别和量化肿瘤乏氧不但可预测预后,对某些患者进行放化疗增敏治疗或增加其乏氧区域的放射剂量,还可改善其预后。可是,使 Hypoxia in tumor tissue is an important biological feature of malignant solid tumors. The degree of hypoxia is closely related to the clinical radiotherapy effect. Many studies have shown that the degree of hypoxia in tumor tissue is positively correlated with the resistance to radiotherapy. Therefore, identifying and quantifying tumor hypoxia not only predicts the prognosis, but also enhances the prognosis by chemoradiation sensitization therapy or radiation dose increase in hypoxic region of some patients. However, so