苯妥英(phonytoin),苯巴比妥(phenobabital),朴痫酮(primidone)和卡马西平(carbamaz-epme)是常用有效的抗癫痫药物,其血药浓度与疗效及毒副作用有密切的关系。尽管近年来有人主张采用单一药物治疗,但对顽固癫痫患者仍经常需用几种药物联合治疗.为了合理用药,做到用药个体化和减少毒副反应,对患者尤其是肝肾功能不全者进行多种药物血浓度测定是十分必要的. Phytoin, phenobabital, primidone and carbamazepine are common and effective antiepileptic drugs, and their plasma concentration is closely related to the curative effect and toxic side effects. Although some people advocate the use of single drug therapy in recent years, patients with stubborn epilepsy often need to use several drugs in combination therapy.In order to rationally use drugs, to achieve personalized medicine and reduce side effects, especially in patients with liver and kidney dysfunction Multiple drug blood concentration is very necessary.