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5. In vitro selected peptides bind with thymidylate synthase mRNA and inhibit its translation

In vitro selected peptides bind with thymidylate synthase mRNA and inhibit its translation

来源 :中国科学：生命科学英文版 | 被引量 : 0次 | 上传用户：sophia971

【摘 要】

：

Thymidylate synthase (TS), an essential enzyme for catalyzing the biosynthesis of thymidylate, is a critical therapeutic target in cancer therapy. Recent studie

【作 者】

：

YAN Song NIU RongLi WANG Zheng 

【机 构】

：

SchoolofEnvironmentalScienceandEngineering,KeyLaboratoryofExperimentalMarineBiology

【出 处】

：

中国科学：生命科学英文版

【发表日期】

：

2007年5期

【关键词】

：

thymidylate synthase MRNA display selection AFFINITY PEPTIDES thymidylate syn 

【基金项目】

：

Supported by the National Natural Science Foundation of China (Grant No. 30472043) and the Department of Science and Technology of Shandong Province (Grant No. 2004C07)

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Thymidylate synthase (TS), an essential enzyme for catalyzing the biosynthesis of thymidylate, is a critical therapeutic target in cancer therapy. Recent studies have shown that TS functions as an RNA-binding protein by interacting with two different sequ

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