二氟苯水杨酸(diflunisal),是一种非皮质类固醇药,具有止痛、消炎和解热效能,用于治疗轻、中度疼痛,骨关节炎和类风湿性关节炎。它对环氧合酶代谢的抑制作用已得到公认,但对眼的作用尚无报道。作者最近意外地注意到,有些用乙酰唑胺治疗的青光眼患者,加用二氟苯水杨酸治疗后,出现眼压降低现象。为确定此事,作者进行了一项临床试验,并研究了二氟苯水杨酸对血浆蛋白结合乙酰唑 Diflunisal, a non-corticosteroid drug, has analgesic, anti-inflammatory and antipyretic properties for the treatment of mild to moderate pain, osteoarthritis and rheumatoid arthritis. Its inhibition of cyclooxygenase metabolism has been recognized, but the role of the eye has not been reported. The authors recently unexpectedly noted that in some patients with glaucoma treated with acetazolamide, there was a reduction in intraocular pressure after treatment with diflunisal. To determine this issue, the authors conducted a clinical trial and studied the effects of diflunisal on plasma protein-binding acetoxazole