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Aim:To investigate the role of histamine in memory deficits induced by MK-801infusion into the ventral hippocampus in rats.Methods:An 8-arm radial maze(4arms baited)was used to assess spatial memory.Results:Bilateral ventralintrahippocampal(ih)infusion of MK-801(0.3 μg/site),an N-methyl-D-aspartate(NMDA)antagonist,impaired the retrieval process in both working memory andreference memory.Intrahippocampal injection of histamine(25 or 50 ng/site)orintraperitoneal(ip)injection of histidine(25,50 or 100 mg/kg)markedly amelio-rated the spatial memory deficits induced by MK-801.Both the histamine H_1 an-tagonist pyrilamine(0.5 or 1.0 μg/site,ih)and the H2 antagonist cimetidine(2.5 μg/site,ih)abolished the ameliorating effect of histidine( 100 mg/kg,ip)on reference memorydeficits,but not that on working memory deficits induced by MK-801.Conclusion:The results indicate that histamine in the ventral hippocampus can ameliorateMK-801-induced spatial memory deficits,and that histamine’s effect on referencememory is mediated by postsynaptic histamine H_1 and H_2 receptors.
Aim: To investigate the role of histamine in memory deficits induced by MK-801infusion into the ventral hippocampus in rats. Methods: An 8-arm radial maze (4arms baited) was used to assess spatial memory. Results: Bilateral ventralintrahippocampal (ih) infusion of MK-801 (0.3 μg / site), an N-methyl-D-aspartate (NMDA) antagonist, impaired in the retrieval process in both working memory and memory of the. volunteer injection of histamine (25 or 50 ng / site) or intraperitoneal ) of the histamine H_1 an-tagonist pyrilamine (0.5 or 1.0 μg / site, ih) and the H2 antagonist (25, 50 or 100 mg / kg) markedly amelio-rated the spatial memory deficits induced by MK- cimetidine (2.5 μg / site, ih) abolished the ameliorating effect of histidine (100 mg / kg, ip) on reference memorydeficits, but not that on working memory deficits induced by MK-801.Conclusion: The results indicate that histamine in the ventral hippocampus can ameliorate MK-801-induced spatial memory deficits, and that histamine’s effect o n referencememory is mediated by postsynaptic histamine H_1 and H_2 receptors.