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26例41岁以前的宫颈癌患者行根治性治疗的同时,2例行卵巢移植术,24例行卵巢移位术。利用B超、测定血清性激素水平等方法定期监测保留卵巢的功能。以探讨年轻早期子宫颈癌患者几种不同保留卵巢手术方式的效果。结果:接受卵巢移植术者,术后6个月卵巢开始周期性增大,术后9~15个月恢复正常。1例随访12a,卵巢功能正常。1例随访10a,术后9a血清性激素值接近绝经期水平。卵巢移位者,未接受放射治疗的9例患者术后卵巢功能正常,卵巢功能持续5~8a,平均62a。15例术后1个月辅助放射治疗,放射治疗结束6个月后,大部分卵巢开始恢复排卵周期。辅助放疗组,933%(14/15)的患者保持卵巢功能,卵巢功能持续4~6a,平均45a。辅助放疗组与未放疗组间卵巢功能持续时间差异有显著性(P<005)。放射治疗组与未接收放疗组5a生存率分别为906%和100%(P>005)。结论:卵巢移位术是一种保留年轻宫颈癌患者卵巢功能的简便有效方法,放射治疗对移位的卵巢功能有不良影响
Twenty-six cases of cervical cancer before the age of 41 were treated with radical treatment. Two cases underwent ovarian transplantation and 24 cases underwent ovarian transposition. The use of B ultrasound, serum hormone levels and other methods to regularly monitor the preservation of ovarian function. To explore the effects of several different methods of preserved ovarian surgery in young early-stage cervical cancer patients. RESULTS: After receiving ovarian transplantation, the ovaries began to increase periodically at 6 months postoperatively and returned to normal 9-15 months after surgery. One patient was followed up for 12 years and her ovarian function was normal. One patient was followed up for 10 years. The postoperative serum hormone level was close to the menopause level. Ovarian shifters, 9 patients who did not receive radiotherapy, had normal ovarian function, and ovarian function continued for 5 to 8 years with an average of 6 to 2 years. Fifteen patients received adjuvant radiotherapy 1 month after surgery. Six months after the end of radiotherapy, most ovaries began to recover their ovulation cycle. In the adjuvant radiotherapy group, 93. 3% (14/15) of patients maintained ovarian function, and ovarian function continued for 4 to 6 years with an average of 4 to 5 years. There was a significant difference in the duration of ovarian function between the adjuvant radiotherapy group and the non-radiotherapy group (P<005). The 5-year survival rate of radiotherapy group and non-receiving radiotherapy group was 906% and 100%, respectively (P>005). Conclusion: Ovarian transposition is a simple and effective method to retain ovarian function in young patients with cervical cancer. Radiotherapy has adverse effects on displaced ovarian function.