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细胞周期素Ｄ1(ｃｙｃｌｉｎＤ1) ,ｐ16和视网膜母细胞瘤蛋白 (ｐＲＢ)是重要的细胞周期调节因子 ,主要作用在Ｇ1→Ｓ期调控点。其作用相互关联 ,以ｐＲＢ为中心构成所谓“ｃｙｃｌｉｎＤ1/ｐ16 ｐＲＢ路径”或“ｐＲＢ路径”。在对其它系统肿瘤研究中发现这一路径存在着广泛的
CyclinD1, p16 and retinoblastoma protein (pRB) are important cell cycle regulators and play a key role in the regulation of G1 → S phase. Their roles are interrelated and the so-called “cyclinD1 / p16 pRB pathway” or “pRB pathway” is centered on pRB. This path has been found extensively in other systemic oncology studies