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吐温-80系非离子表面活性剂,被广泛用作固、液体制剂的乳化剂、助悬剂、润湿剂、分散剂和增溶剂。但用来加速片剂的崩解尚未见报道。笔者应用此辅料,解决了硫糖铝片崩解迟缓及裂片的难题,提高了产品质量。一、实验方法与结果硫糖铝有强疏水性,单用淀粉作崩解剂达不到迅速吸水膨胀崩解的作用。而非离子表面活性剂能增加疏水性固体的润湿性,加速水分的进入,从而加快崩
Tween -80 series of non-ionic surfactants, are widely used as solid, liquid formulations of emulsifiers, suspending agents, wetting agents, dispersants and solubilizers. However, there has been no report on the disintegration of tablets. I use this excipient to solve the sucralfate disintegration slow and lobes of the problem and improve product quality. First, the experimental methods and results sucralfate has a strong hydrophobic, starch alone as a disintegrant can not achieve the role of rapid water swelling and disintegration. Non-ionic surfactants, on the other hand, increase the wettability of hydrophobic solids and accelerate the ingress of moisture, thereby accelerating collapse