为了弄清慢性丙型肝炎患者血清抗-HCV的型别与流行病学、临床特征和病毒复制间的关系,作者进行了研究。研究对象为172例经血清学试验和肝活检证实为非甲非乙型慢性肝炎的患者。对每例患者在作肝活检的同时采取血清标本。用第一代和第二代ELISAs及第二代RIBA作抗-HCV检测,包括抗-5-1、抗-C100-3、抗-C33c、抗-C22。用PCR检测HCV RNA。 In order to understand the relationship between serum anti-HCV genotype and epidemiology, clinical features and viral replication in patients with chronic hepatitis C, the authors studied. The subjects were 172 patients who were confirmed as non-A, B and C by serological tests and liver biopsy. For each patient in the liver biopsy taken at the same time serum samples. Anti-HCV assays were performed with first- and second-generation ELISAs and second-generation RIBA, including anti--5-1, anti-C100-3, anti-C333, anti-C22. HCV RNA was detected by PCR.