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目的对比研究大强度间歇运动与低强度持续运动对高脂喂养大鼠体成分和血清学指标的影响,分析不同运动方式对高脂诱导肥胖症的预防效果。方法37只雄性SD大鼠分为对照饮食安静组(CS)、高脂饮食安静组(HS)、高脂饮食低强度持续运动组(HE)和高脂饮食大强度间歇运动组(HI),喂养10周,运动组分别进行低强度持续运动和大强度间歇运动干预。监测摄食量和体重;造模后测量体脂和血清学指标。结果 (1)HS组终末体重、Lee’s指数、体脂含量显著高于CS组(P<0.01);HS组终末体重较CS组高出15.9%。HI组终末体重和Lee’s指数明显低于HS组(P<0.01)。HE组(P<0.05)和HI组(P<0.01)体脂含量均低于HS组。(2)血清学分析结果显示,HS组血脂(TG,P<0.05;TC,P<0.01;LDL-C,P<0.05)、血糖(P<0.01)含量明显高于CS组;QUICKI指数明显低于CS组(P<0.01)。HI组TG和GLU明显低于HS组(P<0.01),而QUICKI指数明显高于CS组(P<0.01)。(3)相关分析结果显示,QUICKI指数与血糖(r=-0.925,P<0.01)、脂肪含量(r=-0.623,P<0.01)呈显著负相关。结论大强度间歇运动可有效地预防高脂饮食诱导的肥胖症,其干预效果明显优于低强度持续运动方式。
Objective To compare the effects of high-intensity intermittent exercise and low-intensity continuous exercise on body composition and serological parameters of rats fed with high fat diet and to analyze the preventive effects of different exercise modes on high fat-induced obesity. Methods Thirty-seven male Sprague-Dawley rats were randomly divided into four groups: control, tranquilized diet group (CS), high fat diet resting group (HS), high fat diet low intensity exercise group (HE) and high fat diet high intensity exercise group Feeding for 10 weeks, the exercise group were engaged in low intensity continuous exercise and high intensity intermittent exercise intervention. Food intake and body weight were monitored. Body fat and serological parameters were measured after modeling. Results (1) The body weight, Lee’s index and body fat content in HS group were significantly higher than those in CS group (P <0.01). The body weight of HS group was 15.9% higher than that in CS group. The body weight and Lee’s index of HI group were significantly lower than those of HS group (P <0.01). Body fat content in HE group (P <0.05) and HI group (P <0.01) were lower than that in HS group. (2) The results of serological analysis showed that the levels of serum lipid (TG, P <0.05; TC, P <0.01, LDL-C, P < Lower than CS group (P <0.01). TG and GLU in HI group were significantly lower than those in HS group (P <0.01), and QUICKI index was significantly higher than that in CS group (P <0.01). (3) The correlation analysis showed that the QUICKI index was significantly negatively correlated with the blood glucose (r = -0.925, P <0.01) and the fat content (r = -0.623, P <0.01). Conclusion High-intensity intermittent exercise can effectively prevent obesity induced by high-fat diet and its intervention effect is obviously better than low-intensity continuous exercise.