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在临床核医学诊断中,~(99m)锝由于有理想的核性质而成为核医学中使用最广泛的同位素。~(99m)Tc可用于显示脑、肾、肺、肝、骨等器官,但至今仍不能用现有的~(99m)Tc核素制剂显示正常心肌。目前,已知能在心脏组织中聚集的阳离子同位素有~(48)钾、~(81)铷、~(129)铯和~(201)铊,它们都被用于提供心脏的γ照相,这些阳离子通过钠-钾依赖的ATP系统、以类似K~+的功能被心肌细胞摄取。其中,~(201)Tl最常用,然而,与~(99m)Tc相比,~(201)Tl的放射性很弱,γ线能量太低,为了获得一个清晰的图象需给以病人较大的剂量,它的价格又昂贵,因而不是一种理想的心脏显影剂。作者发现,~(99m)Tc的+1价络合物有类似以上阳
In clinical nuclear medicine diagnosis, ~ (99m) technetium becomes the most widely used isotope in nuclear medicine because of its ideal nuclear properties. ~ (99m) Tc can be used to display brain, kidney, lung, liver, bone and other organs, but up to now the existing 99m Tc nuclide preparations can not show normal myocardium. At present, it is known that there are ~ (48) potassium, ~ (81) rubidium, ~ 129 cesium and ~ (201) thallium in the cardiac tissues, all of which are used to provide gamma photography of the heart. These cations Through the sodium-potassium-dependent ATP system, K + -like functions are taken up by cardiomyocytes. Among them, ~ (201) Tl is most commonly used, however, ~ (201) Tl is radioactively weaker than gamma-99m Tc, and gamma-ray energy is too low. In order to obtain a clear image, It is expensive and therefore not an ideal cardiac developer. The authors found that the ~ (99m) Tc +1 complex has a similar positivity