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目的探讨环氧化酶-2(COX-2)和Ki-67在乳腺浸润性导管癌组织中的表达情况及其临床意义。方法采用免疫组织化学SP方法检测82例乳腺浸润性导管癌组织和相应癌旁正常组织中COX-2和Ki-67蛋白表达,并分析二者表达的相关性以及其表达与乳腺浸润性导管癌患者临床病理特征的关系。结果①在82例乳腺浸润性导管癌组织中COX-2和Ki-67蛋白表达阳性率均分别明显高于其在相应癌旁正常组织中的表达阳性率〔COX-2:71.95%(59/82)比8.54%(7/82),χ2=68.56,P<0.001;Ki-67:64.63%(53/82)比13.42%(11/82),χ2=45.20,P<0.001〕。②COX-2和Ki-67蛋白阳性表达与肿瘤TNM分期(COX-2:rs=0.349,P<0.05;Ki-67:rs=0.305,P<0.05)、淋巴结转移(COX-2:rs=0.336,P<0.05;Ki-67:rs=0.419,P<0.01)、脉管侵犯(COX-2:rs=0.235,P<0.05;Ki-67:rs=0.461,P<0.01)及组织学分级(COX-2:rs=0.434,P<0.01;Ki-67:rs=0.378,P<0.05)均呈正相关;Ki-67蛋白阳性表达与肿瘤直径呈正相关(rs=0.365,P<0.01),而COX-2蛋白阳性表达与此无关(rs=0.135,P>0.05);COX-2和Ki-67蛋白阳性表达皆与患者是否绝经无关(COX-2:rs=0.172,P>0.05;Ki-67:rs=0.163,P>0.05)。③在浸润性导管癌组织中COX-2和Ki-67蛋白阳性表达呈正相关性(rs=0.475,P<0.01)。结论在乳腺浸润性导管癌组织中COX-2和Ki-67的表达均增高,两者与乳腺浸润性导管癌临床病理特征密切相关,对两者进行联合检测可反映乳腺浸润性导管癌的生物学行为,COX-2有可能成为乳腺癌治疗的一个新靶点。
Objective To investigate the expression of cyclooxygenase-2 (COX-2) and Ki-67 in invasive ductal carcinoma of the breast and its clinical significance. Methods The expressions of COX-2 and Ki-67 protein in 82 invasive ductal carcinomas and adjacent normal tissues were detected by immunohistochemical SP method. The correlation between the expression of COX-2 and Ki-67 protein and the expression of COX-2 and Ki-67 in infiltrating ductal carcinoma The relationship between the clinicopathological characteristics of patients. Results ① The positive expression rates of COX-2 and Ki-67 in 82 cases of invasive ductal carcinoma of the breast were significantly higher than those in the corresponding normal tissues (COX-2: 71.95%, 59 / 82) than 8.54% (7/82), χ2 = 68.56, P <0.001; Ki-67: 64.63% (53/82) vs 13.42% (11/82), χ2 = 45.20, P <0.001. The positive expression of COX-2 and Ki-67 protein was positively correlated with TNM stage (COX-2: rs = 0.349, P <0.05; Ki-67: rs = 0.305, , P <0.05, Ki-67: rs = 0.419, P <0.01), vascular invasion (COX-2: rs = 0.235, There was a positive correlation between the expression of Ki-67 and tumor diameter (rs = 0.365, P <0.01) However, the positive expression of COX-2 protein was not related to this (rs = 0.135, P> 0.05). The positive expressions of COX-2 and Ki-67 protein were not related to whether the patients had menopause (COX-2: rs = 0.172, P> -67: rs = 0.163, P> 0.05). ③ The positive expression of COX-2 and Ki-67 in invasive ductal carcinoma was positively correlated (rs = 0.475, P <0.01). Conclusions The expressions of COX-2 and Ki-67 in invasive ductal carcinoma of the breast are both higher than that of the invasive ductal carcinoma. Both of them are closely related to the clinicopathological features of invasive ductal carcinoma of the breast. The combined detection of both can reflect the biological characteristics of invasive ductal carcinoma of the breast Learning behavior, COX-2 may become a new target for the treatment of breast cancer.