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目的探讨系统性红斑狼疮（SLE）患者血清中抗中性粒细胞胞浆抗体（ANCA）的阳性检出率及其与病情的相关性。方法应用间接免疫荧光技术（IIF）检测。结果120例SLE患者中，ANCA阳性对例，阳性率25．8％。其中P-ANCA阳性者20例，阳性率16．6％；G-ANCA阳性者11例，阳性率9．2％；且滴度越高临床病情越重。66例活动组SLE中ANCA阳性为23例，阳性率为34．8％，明显高于非活动组54例中的8例阳性率14.8％（P＜0．05）。正常对照20例均为阴性。结论ANCA在SLE患者中有一定的阳性检出率，且与疾病的严重程度具有相关性。
Objective To investigate the positive detection rate of anti-neutrophil cytoplasmic antibody (ANCA) in sera of patients with systemic lupus erythematosus (SLE) and its relationship with the disease. Methods Indirect immunofluorescence assay (IIF) was used. Results Of 120 SLE patients, ANCA positive cases, the positive rate of 25.8%. Among them, 20 were positive for P-ANCA, the positive rate was 16.6%; 11 were positive for G-ANCA, the positive rate was 9.2%; and the higher the titer was, the more severe the clinical condition was. The positive rate of ANCA in 66 cases of active SLE was 23 cases, the positive rate was 34.8%, which was significantly higher than that of 8 cases in inactive group (14.8%, P <0.05). 20 cases of normal control were negative. Conclusions ANCA has a positive detection rate in patients with SLE and is correlated with the severity of the disease.