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目的:观察七味都气方联合倍氯米松治疗咳嗽变异性哮喘的临床疗效。方法:将确诊为咳嗽变异性哮喘的72例患者随机分为2组,治疗组36例予以口服七味都气方加减联合吸入倍氯米松,对照组36例予以吸入倍氯米松。2组疗程均为8周,观察2组治疗前后患者临床症状、诱导痰嗜酸性粒细胞百分比的变化以及计算临床控制率。结果:治疗8周后,2组咳嗽程度积分、诱导痰嗜酸性粒细胞百分比均较治疗前下降(P<0.05);治疗组咳嗽程度积分、诱导痰嗜酸性粒细胞百分比均低于对照组(P<0.05)。临床控制率治疗组为91.67%,对照组为80.56%。结论:七味都气方加减联合倍氯米松治疗咳嗽变异性哮喘,可更好地缓解患者的临床症状以及降低气道嗜酸性粒细胞比例,达到更高的临床控制率。
Objective: To observe the clinical effect of Qiwei Duqi Recipe combined with beclometasone in the treatment of cough variant asthma. Methods: Seventy-two patients diagnosed with cough variant asthma were randomly divided into two groups. 36 patients in the treatment group were treated with qiweichai qi decoction combined with inhaled beclomethasone, and 36 in the control group were given beclometasone. The two groups were treated for 8 weeks. The clinical symptoms, the percentage of induced sputum eosinophils and the clinical control rate were observed before and after treatment in both groups. Results: After 8 weeks of treatment, the scores of cough level and induced sputum eosinophil in both groups were significantly lower than those before treatment (P <0.05). The scores of cough level and induced sputum eosinophil in the treatment group were lower than those in the control group P <0.05). The clinical control rate was 91.67% in the treatment group and 80.56% in the control group. Conclusion: The combination of Qiweiduqi recipe and beclomethasone in treatment of cough variant asthma can better alleviate the clinical symptoms and reduce the proportion of airway eosinophils, and achieve a higher clinical control rate.