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各种先天性视网膜疾病的发病机制以及视网膜神经损伤后的再生修复均与视网膜的胚胎发育发生有着密切的关系 ,随着分子生物学向神经科学和胚胎发生学领域的渗透 ,人们正在逐步揭开视网膜胚胎发育发生的奥秘。本文在阐述视网膜分化发育过程中δ Notch信号通路和表皮生长因子受体(EGF R)水平的微观调控机制的基础上 ,进一步对视黄酸在视网膜发育中的诱导分化作用及其它营养因子如转化生长因子 (FGF)、神经营养素和二十二碳六烯酸在胚胎视网膜发育中的作用作一综述。
The pathogenesis of various congenital retinal diseases and retinal nerve injury after regeneration and repair are associated with retinal embryonic development has a close relationship with the molecular biology to neuroscience and embryology in the field of penetration, people are gradually unraveling The mystery of retinal embryonic development. Based on the micro-regulation mechanism of delta Notch signaling pathway and epidermal growth factor receptor (EGFR) in the process of retinal differentiation and development, further studies on the differentiation and differentiation of retinoic acid in retinal development and other nutritional factors such as transformation The role of growth factor (FGF), neurotrophins and docosahexaenoic acid in the development of embryonic retina is reviewed.