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近年来随着杂交瘤技术的进展,特异性单克隆抗体(下简称单抗)的制备和应用,已成为医学上一个热门的新课题。在血液学方面,采用体细胞融合技术。将正常或肿瘤性白细胞抗原免疫后的小鼠 B 细胞与骨髓瘤细胞进行杂交,已能制备多种对正常或肿瘤性淋巴细胞、粒细胞及单核细胞的表面抗原有特异性结合能力的单克隆抗体。这些单克隆抗体不仅可用于研究正常淋巴细胞及造血细胞的分化和组织分布,而且已用于临床研究。目前在国外,抗
In recent years, with the progress of hybridoma technology, the preparation and application of specific monoclonal antibody (mAb) has become a hot new topic in medicine. In hematology, somatic fusion is used. Hybridization of mouse B cells with myeloma cells after immunization of normal or neoplastic leukocyte antigens has resulted in the preparation of a variety of single-specific monoclonal antibodies that bind specifically to surface antigens of normal or neoplastic lymphocytes, granulocytes and monocytes Clone antibody. These monoclonal antibodies are useful not only for studying the differentiation and tissue distribution of normal lymphocytes and hematopoietic cells but also for clinical research. Currently in foreign countries, resistance