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脂质过氧化过程产生的自由基及其产物可以损伤细胞膜、蛋白质和DNA,进而可能导致癌症及某些心、脑和血管疾病的发生。脂质过氧化还是衰老的重要因素,但是,多数研究者仅以脂质过氧化的最终产物之一丙二醛(MDA)作为指标。而脂质过氧化是一个自由基链式反应过程,分为链起动、链扩展和链终止三步进行,其中每一步都有自由基中间物产生和参与。这些自由基多是寿命极短、反应性极强、对生物分子的损伤作用比丙二醛大很多倍。因
Free radicals produced by lipid peroxidation and their products can damage cell membranes, proteins and DNA, which in turn can lead to cancer and certain heart, brain and vascular diseases. Lipid peroxidation is also an important factor in aging, but most researchers only use malondialdehyde (MDA), one of the end products of lipid peroxidation, as an indicator. Lipid peroxidation is a free radical chain reaction process, which is divided into three steps: chain initiation, chain extension and chain termination. Each step has the generation and participation of free radical intermediates. These free radicals are very short life expectancy, highly reactive, the role of damage to biomolecules much larger than the malondialdehyde. because