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目的分析四川省HIV-1抗病毒治疗1年以上病例耐药现状和影响因素。方法对治疗1年以上的患者进行病毒载量检测,病毒载量大于1 000 IU/ml进行核酸PCR和pol基因测序,登录美国斯坦福大学HIV耐药数据库在线分析耐药突变情况。结果 1 149例病例中981例(85.38%)小于病毒载量最低检测限,88例(7.66%)病毒载量大于1 000IU/ml,有40例(3.48%)耐药,其中3例对蛋白酶抑制剂(PIs)耐药;28例对核苷类逆转录酶抑制剂(NRTIs)耐药;39例对非核苷类逆转录酶抑制剂(NNRTIs)耐药。结论四川省目前HIV-1耐药总体程度较低,已出现耐药病例中,NNTRIs交叉耐药较为严重,部分对NRTIs全部耐药。
Objective To analyze the current situation and influential factors of drug resistance of HIV-1 antiviral therapy in Sichuan province for more than one year. Methods The viral load was tested in patients who were treated for more than 1 year. The viral load was greater than 1 000 IU / ml for nucleic acid PCR and pol gene sequencing. The resistance database was analyzed online at the Stanford HIV Drug Resistance database. Results 981 (85.38%) of the 1 149 cases were less than the lowest detection limit of viral load, 88 cases (7.66%) had viral load greater than 1 000 IU / ml and 40 cases (3.48%) were resistant, (PIs) resistant; 28 cases resistant to nucleoside reverse transcriptase inhibitors (NRTIs); 39 cases resistant to non-nucleoside reverse transcriptase inhibitors (NNRTIs). Conclusion The overall HIV-1 resistance in Sichuan Province is relatively low at present. Among the resistant cases that have emerged, NNTRIs are more cross-resistant and partly resistant to NRTIs.