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目的:通过对HBsAg阳性人群家庭成员中大于15岁HBsAg阴性成员进行抗-HBs水平的定量检测,了解其免疫前后抗-HBs水平的变化,为慢性HBV感染者人群密切接触者免疫预防与控制和成人乙肝疫苗免疫策略提供重要的科学依据。方法:采用微粒子酶免疫分析技术(MEIA)[1]。结果:2010年对我市的两个自然村HBsAg阳性人群家庭成员中大于15岁HBsAg阴性成员共30人进行了抗-HBs水平的定量检测,其中免疫前<10 mIU/ml 8人,占26.7%;10 mIU/ml～50 mIU/ml 9人,占30.0%;50 mIU/ml～100 mIU/ml 7人,占23.3%;>100 mIU/ml 6人,占20.0%;平均GMT为112.48 mIU/ml;免疫后<10 mIU/ml 1人,占3.3%;>100 mIU/ml 29人,占96.7%;平均GMT为712.51 mIU/ml。结论:经过乙肝疫苗的接种后,抗-HBs水平都呈明显的上升,因而HBsAg阳性人群家庭成员可通过接种乙肝疫苗来预防与控制HBsAg阳性人群通过水平或性传播等方式造成家庭成员的HBV的感染。
OBJECTIVE: To detect the level of anti-HBs in HBsAg-negative female members of HBsAg-positive population aged> 15 years before and after immunization to detect the level of anti-HBs, and to study the immune prevention and control of close contacts among people with chronic HBV infection and Adult hepatitis B vaccine immunization strategy provides an important scientific basis. Methods: Microparticle enzyme immunoassay (MEIA) [1]. Results: In 2010, a total of 30 HBsAg-negative female members of more than 15 years of age from two HBsAg-positive population in our village were tested for anti-HBs level. Among them, 8 were pre-immune <10 mIU / ml, accounting for 26.7% ; 10 mIU / ml ~ 50 mIU / ml 9, accounting for 30.0%; 50 mIU / ml ~ 100 mIU / ml 7 people, accounting for 23.3%;> 100 mIU / ml 6, accounting for 20.0%; the average GMT was 112.48 mIU / ml; immunized <10 mIU / ml 1, accounting for 3.3%;> 100 mIU / ml 29, accounting for 96.7%; average GMT was 712.51 mIU / ml. Conclusion: The anti-HBs levels in patients with HBsAg positive population can be prevented and controlled by hepatitis B vaccine after inoculation of hepatitis B vaccine. The levels of HBV in family members infection.