细胞免疫在肿瘤的免疫应答中占主导地位,以往人们更多地关注CD8+CTL细胞反应,而忽视了CD4+Th细胞的作用。随着CD4+Th细胞对于诱导、维持和增殖CD8+T细胞作用的不断发现,许多学者希望通过同时激活CD4+Th和CD8+CTL细胞来增强抗肿瘤免疫效果。运用肿瘤全抗原、融合蛋白、融合细胞、靶向于树突状细胞恒定链以及TCR转染等手段,大量尝试显示初步结果令人满意。同时激活CD4+Th和CD8+CTL细胞可能成为诱导抗肿瘤免疫的一个理想策略。 Cellular immunity plays a dominant role in the immune response of tumors. In the past, people paid more attention to the response of CD8+ CTL cells and ignored the role of CD4+ Th cells. With the continuous discovery of the role of CD4+ Th cells in inducing, maintaining and proliferating CD8+ T cells, many scholars hope to enhance anti-tumor immunity by simultaneously activating CD4+ Th and CD8+ CTL cells. The use of total tumor antigens, fusion proteins, fused cells, targeting dendritic cells invariant chains, and TCR transfections, a number of attempts have shown that the preliminary results are satisfactory. Simultaneous activation of CD4+ Th and CD8+ CTL cells may be an ideal strategy for inducing anti-tumor immunity.