大量基础研究表明,哺乳动物中枢神经系统(CNS)损伤后神经再生受限的主要原因是轴突生长抑制因子的存在。研究者试图通过不同的方法来中和或破坏髓鞘,清除髓鞘相关抑制分子,从而达到促进脊髓损伤后轴突再生和神经功能恢复的目的。目前,与Nogo蛋白相关的药物和基因治疗已成为CNS损伤后促进轴突再生新的有效手段,现对其研究进展作一综述。 Numerous basic studies have shown that the main reason for the limited regenerative nerve regeneration following a central nervous system (CNS) injury in mammals is the presence of axon growth inhibitory factor. The researchers tried to neutralize or destroy the myelin by different methods to remove myelin-related inhibitory molecules, so as to achieve the purpose of promoting axon regeneration and nerve function recovery after spinal cord injury. At present, the drugs and gene therapy related to Nogo protein have become new and effective methods to promote axon regeneration after CNS injury. The progress of their research is reviewed.