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为观察自由基清除剂甘露醇对急性出血坏死性胰腺炎（ＡＨＮＰ）的治疗作用，在２８只Ｗｉｓｔａｒ大鼠胰管内逆行注入牛胆汁酸钠，造成ＡＨＮＰ模型后随机分成治疗组和对照组。治疗组大鼠以２０％甘露醇（１ｇ／ｋｇ）于尾静脉缓慢推注，１次／１２小时，直至实验结束。对照组以同样方法及间隔时间给予生理盐水（５．０ｍｌ／ｋｇ）。两组大鼠均于９６小时采心脏血后处死。结果：治疗组胰腺组织中过氧化脂质（ＬＰＯ）、血清中ＬＰＯ、乳酸脱氢酶（ＬＤＨ）、α１抗胰蛋白酶（α１ＡＴ）、谷草转氨酶（ＧＯＴ）和胰腺组织坏死面积均显著低于对照组（Ｐ＜０．０１或Ｐ＜０．０５）。光镜下治疗组胰腺、肝脏、心脏、肾脏的损害亦轻于对照组。治疗组大鼠死亡率显著低于对照组（Ｐ＜０．０５）。由此表明：甘露醇能够清除自由基，减轻ＡＨＮＰ胰腺及其全身脏器的损害
To observe the therapeutic effect of free radical scavenger mannitol on acute hemorrhagic necrotizing pancreatitis (AHNP), 28 cases of Wistar rats were retrogradely injected with bile sodium bile into the pancreatic duct, which caused the AHNP model to be randomly divided into treatment group and control group. Rats in the treatment group were slowly bolted to the tail vein with 20% mannitol (1 g / kg) once / 12 hours until the end of the experiment. The control group was given saline (5.0 ml / kg) in the same way and at intervals. Both groups of rats were sacrificed after 96 hours of collecting blood. Results: The contents of LPO, LPO, LDH, α1AT, GOT and pancreas necrosis area in the pancreas of the treatment group were significantly Lower than the control group (P <0.01 or P <0.05). Light microscope treatment group pancreas, liver, heart, kidney damage is also lighter than the control group. The treatment group rats mortality was significantly lower than the control group (P <0.05). This shows that: mannitol can scavenge free radicals, reduce damage to the AHNP pancreas and its organs