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药物诱发狼疮指服用某种药物而出现全身性红斑狼疮样症状和抗核抗体的疾病。其特征是停用诱发药物后,临床症状迅速改善。自1953年发现服用肼苯哒嗪引起本病以来,已报道有多种药物引起本病。目前,肼苯哒嗪、普鲁卡因酰胺和异烟肼被认为与本病高度相关。药物诱发的狼疮作为红斑狼疮的模型受到重视,特别是可进行有关其发病机制的各种研究。
Drug-induced lupus refers to taking certain drugs and systemic lupus erythematosus-like symptoms and anti-nuclear antibody disease. It is characterized by the withdrawal of induced drugs, the rapid improvement of clinical symptoms. Since the discovery of hydralazine in 1953, it has been reported that many drugs have caused this disease. Currently, hydralazine, procainamide and isoniazid are considered highly relevant to this disease. Drug-induced lupus is regarded as a model of lupus erythematosus, and in particular, various studies on its pathogenesis can be conducted.