论文部分内容阅读
目的:探讨新疆维吾尔族妇女宫颈上皮内瘤样病变(CIN)及宫颈癌组织中VEGF-C的表达及其与临床病理特征的关系。方法:应用免疫组化方法检测慢性宫颈炎22例、CIN24例及宫颈癌活检与手术切除43例标本中VEGF-C的表达,并与临床病理参数进行比较分析。结果:慢性宫颈炎、CIN及宫颈癌组中VEGF-C阳性表达率分别为9.1%、87.5%、100.0%,差异有统计学意义(P<0.01);VEGF-C在临床Ⅰ～Ⅱ期和Ⅲ～Ⅳ期宫颈癌组中强阳性表达率分别是44.1%、88.9%,差异有统计学意义(P<0.05);在组织分化1～2级和3级的宫颈癌患者中强阳性表达率分别是51.6%和58.3%,差异无统计学意义(P>0.05);在肿瘤直径≤4cm的宫颈癌组织中的强阳性表达率是40.0%,>4cm的宫颈癌组织中的强阳性表达率是72.2%,差异有统计学意义(P<0.05);CT显示有淋巴结肿大的宫颈癌组织中VEGF-C的阳性表达率是65.5%,高于无淋巴结肿大的宫颈癌组织中的阳性表达率28.6%,差异有统计学意义(P<0.05);早期手术的24例宫颈癌标本中没有淋巴浸润及有淋巴浸润VEGF-C强阳性表达率分别是55.6%和50.0%,差异无统计学意义(P>0.05);在肿瘤浸润宫颈浅肌层与深肌层VEGF-C强阳性表达率分别是50.0%和60.0%,差异无统计学意义(P>0.05)。结论:新疆维吾尔族妇女宫颈癌组织中VEGF-C阳性的表达与临床分期、肿瘤的大小及CT显示淋巴结肿大呈显著相关,与组织学分化、肿瘤浸润的程度及淋巴结的浸润无关。
Objective: To investigate the expression of VEGF-C in cervical intraepithelial neoplasia (CIN) and cervical cancer in Uighur women in Xinjiang and its relationship with clinicopathological features. Methods: Immunohistochemical method was used to detect the expression of VEGF-C in 22 cases of chronic cervicitis, 24 cases of CIN and 43 cases of cervical cancer biopsy and resection, and compared with clinicopathological parameters. Results: The positive rate of VEGF-C in chronic cervicitis, CIN and cervical cancer group was 9.1%, 87.5% and 100.0%, respectively, with statistical significance (P <0.01) The strong positive expression rates in stage Ⅲ ~ Ⅳ cervical cancer were 44.1% and 88.9%, respectively, with significant difference (P <0.05). In cervical cancer patients with histological grade 1 ~ 2 and 3, the strong positive rates Were 51.6% and 58.3%, respectively, with no significant difference (P> 0.05). The strong positive expression rates in cervical cancer tissues with a diameter of less than 4 cm were 40.0% and strong positive rates were more than 4 cm in cervical cancer tissues (72.2%), the difference was statistically significant (P <0.05). The positive rate of VEGF-C expression in cervical cancer with lymph node enlargement was 65.5% by CT, which was higher than that in cervical cancer without lymph node enlargement The positive rate of VEGF-C in 24 cases of cervical cancer without early invasion was 55.6% and 50.0%, respectively, and the difference was statistically significant (P <0.05) (P> 0.05). The strong positive rates of VEGF-C expression in the superficial and myometrial tumor tissues were 50.0% and 60.0%, respectively, with no significant difference (P> 0.05) .05). Conclusion: The expression of VEGF-C in Uighur women with cervical cancer is closely related to the clinical stage, the size of the tumor and the CT findings of lymph node enlargement. It has no relation with histological differentiation, the degree of tumor infiltration and the infiltration of lymph nodes.