动脉粥样硬化(以下简称AS)的并发症,是人类死亡的主要原因之一。关于AS发病机理有多种假说。近10年由于单克隆抗体技术和基因调控等分子生物学技术的应用,人们更多地注意到血管内皮细胞、平滑肌细胞、单核/巨噬细胞及血小板在AS的发生、发展过程中的相互作用。在某些致病因素作用下,这些细胞通过产生生物活性物质而相互影响,决定着AS的发生和发展。 Atherosclerosis (hereinafter referred to as AS) complications, is one of the major causes of human death. There are many hypotheses about the pathogenesis of AS. Nearly 10 years due to the application of molecular biology techniques such as monoclonal antibody technology and gene regulation, people pay more attention to the mutual occurrence of vascular endothelial cells, smooth muscle cells, monocytes / macrophages and platelets in the development of AS effect. Under certain pathogenic factors, these cells interact with each other through the production of bioactive substances, which determine the occurrence and development of AS.