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OK432是作为抗癌剂在临床上广泛应用的生物学免疫应答调节剂(BRM),经动物实验发现BRM 对病毒感染也有防卫作用。尽管OK432抗病毒机理不明确,但对病毒无直接作用,能增强NK 细胞活性,诱发INF及活化细胞毒性巨噬细胞。IFN 对病毒感染细胞有直接作用,抑制病毒增殖,松森等人曾报道rIFNαA/D 对EMC 病毒所致病毒性心肌炎有防卫作用,但是在感染后再应用时
OK432 is a biological immune response regulator (BRM) widely used clinically as an anti-cancer agent. It has been found through animal experiments that BRM also has a protective effect against virus infection. Although OK432 antiviral mechanism is not clear, but no direct effect on the virus, can enhance NK cell activity, induced INF and activated cytotoxic macrophages. IFN has a direct effect on virus-infected cells and inhibits virus proliferation. Matsumura et al. Have reported that rIFNαA / D has a protective effect against viral myocarditis caused by EMC virus, but when applied after infection