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为了建立国人脑脊液中cAMP和cGMP的正常值,作者用放射免疫分析法测定了93例正常脑脊液中cAMP和cGMP浓度,其值分别为20.3±6.2(14.0～28.0),2.1±0.8(1.0～2.9)pmol/ml且cAMP/cGMP比值为10.3±2.9(7.0～13.4)。cAMP和cGMP浓度与年龄、性别无关。为了探讨测得正常值的可靠性,从特异性、精确性、准确性和灵敏度四个方面设计了一些实验,进行方法可靠性的验证,最后证实本文正常值的测定结果准确可靠。
In order to establish the normal values of cAMP and cGMP in cerebrospinal fluid of Chinese people, the concentrations of cAMP and cGMP in 93 normal cerebrospinal fluid were measured by radioimmunoassay and the values were 20.3 ± 6.2 (14.0-28.0) and 2.1 ± 0.8 (1.0-2.9 ) pmol / ml and a cAMP / cGMP ratio of 10.3 ± 2.9 (7.0 to 13.4). cAMP and cGMP concentration has nothing to do with age and sex. In order to explore the reliability of measured normal values, some experiments were designed from the four aspects of specificity, accuracy, accuracy and sensitivity to verify the reliability of the method. Finally, the results of normal values in this paper were confirmed to be accurate and reliable.